I use a 1 image per card system so I have a 52 loci memory palace. When I’m practicing, I just reuse the same memory palace. Should I create more memory palaces to switch between? What do other people do?
If you’re able to manage one palace without any ghosting from each practice run, then I don’t see any reason why you would have to have multiple palaces. If you do occasionally notice some ghosting, though, I’d suggest having maybe a half-dozen palaces and then cycle through them. Chances are, by the time you return to palace #1, you’ll have forgotten all of the cards you’ve stored there and can start fresh.
If you haven’t decided on a preference yet, there are some various opinions in these threads: